Current Surgical Perspectives for Pleural Mesothelioma.

Authors

Simon Esteva, Fereidoun Abtin, Gregory A Fishbein, Robert B Cameron, Bryan M Burt, Jane Yanagawa

Published in

Journal of the National Comprehensive Cancer Network : JNCCN. Volume 24. Issue 8.

Abstract

This review summarizes the current NCCN recommendations for the surgical management of pleural mesothelioma, highlighting the clinical trials and retrospective analyses that have shaped current practice and informed guideline recommendations. Advances in systemic therapy, surgical technique, and radiation therapy have shifted management toward multidisciplinary care. Contemporary treatment paradigms emphasize the importance of histology, stage, performance status, and institutional expertise when considering surgical intervention. Surgery can still be considered part of the multimodality treatment strategy in carefully selected patients, despite recent evidence suggesting its possible lack of benefit. Further investigation is required to improve patient stratification, refine multimodal regimens, and develop novel therapeutic approaches. This review aims to provide a contemporary framework for understanding the current role of surgery within the broader management of pleural mesothelioma.

PMID:
42607714
Bibliographic data and abstract were imported from PubMed on 18 Aug 2026.

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