Tetanus after trauma despite post-exposure prophylaxis with human tetanus immunoglobulin: A case report.

Authors

Xuan Chen, Xiu Liu, Haijun Cao, Jianxia Zhang, Si Liu

Published in

Chinese journal of traumatology = Zhonghua chuang shang za zhi. Aug 08, 2026. Epub Aug 08, 2026.

Abstract

Tetanus is an acute, life-threatening disease caused by Clostridium tetani infection through breaches in the skin or mucous membranes, typically following traumatic injury. While human tetanus immunoglobulin (HTIG) is the preferred passive immunizing agent, documented cases of prophylaxis failure are rare despite theoretical possibilities. We present a case of generalized tetanus that developed 1 month after HTIG administration following trauma. This report highlights the potential failure of HTIG prophylaxis and analyzes its contributing factors to inform clinical practice.

PMID:
42608223
Bibliographic data and abstract were imported from PubMed on 18 Aug 2026.

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