Authors
Hang Pan, Hongxuan Yu, Rui Liu, Liru Zhou, Zehua Wang, Qiong Liu, Guizhen Wang
Published in
Journal of microbiology and biotechnology. Volume 36. Pages e2602009. Jul 29, 2026. Epub Jul 29, 2026.
Abstract
Schisandra chinensis Baill. and its dried ripe fruit, Schisandrae chinensis Fructus, are typical medicinal and edible resources in traditional Chinese medicine. Modern studies indicate that this medicinal material contains lignans, polysaccharides, volatile oils, triterpenoids, flavonoids, and other constituents, among which lignans are the most characteristic pharmacodynamic material basis. Based on the literature covered in this review, this paper summarizes the main bioactive components and structural features of S. chinensis and reviews the pharmacological evidence for antioxidation, anti-inflammatory activity, anti-tumor activity, sedative-hypnotic effects, hepatoprotection, neuroprotection, and metabolic regulation. The currently direct compound-specific evidence is relatively clearer for schisandrin B, schisandrol A/B, and schisanhenol in selected experimental models, whereas several other reported activities still rely mainly on extract-level studies, network pharmacology, or indirect inference. This review aims to provide an evidence-based reference for clarifying the pharmacodynamic material basis, improving quality evaluation, and guiding further mechanistic and clinical studies of S. chinensis Fructus.
PMID:
42608133
Bibliographic data and abstract were imported from PubMed on 18 Aug 2026.
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