Atypical Lentiginous Melanocytic Proliferations Case Series: Relationship to Type II Dysplastic Nevi and Lentiginous Melanoma.

Authors

Maged Daruish, Ella De Ryck, Laura Gadeyne, Julie Lemahieu, Siebe Loontiens, Joni Van Der Meulen, Marc Haspeslagh, Boris C Bastian, Saleem Taibjee

Published in

Journal of cutaneous pathology. Aug 18, 2026. Epub Aug 18, 2026.

Abstract

A recent study described a distinctive subset of dysplastic nevi in older patients, genetically characterized by non-BRAFV600E driver mutations and frequent TERT promoter mutations. It has been proposed that these lesions overlap with the so-called lentiginous dysplastic nevi of the elderly. We explore this relationship in a series of 24 atypical lentiginous melanocytic proliferations, correlating with ex vivo dermoscopy, as well as immunohistochemical and molecular findings. We also discuss the utility of the MPATH-Dx tool to improve consensus for such lesions.

PMID:
42609158
Bibliographic data and abstract were imported from PubMed on 18 Aug 2026.

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