[Autoimmune Autonomic Ganglionopathy].

Authors

Shunya Nakane

Published in

Brain and nerve = Shinkei kenkyu no shinpo. Volume 78. Issue 8. Pages 905-912.

Abstract

Autoimmune autonomic ganglionopathy (AAG) is a peripheral neuropathy caused by immune-mediated synaptic transmission dysfunction in autonomic ganglia. Autoantibodies against the nicotinic ganglionic acetylcholine receptor (gAChR) have been detected in the sera of patients with AAG, and gAChR antibodies are considered pathogenic autoantibodies in AAG. In this review, we discuss recent clinical and research developments in AAG, focusing on the following: (1)reports on the clinical features of AAG and immunotherapy; (2)the association between COVID-19, COVID-19 vaccination, and autonomic dysfunction; (3)autonomic dysfunction as an immune-related adverse effect of immune checkpoint inhibitors in cancer treatment; and (4)new methods for measuring gAChR antibodies.

PMID:
42609149
Bibliographic data and abstract were imported from PubMed on 18 Aug 2026.

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