Association of Dietary Inflammatory Index and Dietary Oxidative Balance Score with Mortality Among Individuals with Cardiovascular-Kidney-Metabolic Syndrome.

Authors

Xiaohua Wang, Hewanmeng Geng, Zihang Yue, Jiaqi Zhang, Siyu Liu, Chengxiang Hu, Zhirong Li, Yue He, Yanan Ma, Lina Jin

Published in

High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension. Aug 18, 2026. Epub Aug 18, 2026.

Abstract

Cardiovascular-kidney-metabolic (CKM) syndrome represents a complex interplay of cardiovascular, kidney, and metabolic disorders. Dietary factors, particularly those with pro-inflammatory and pro-oxidant properties, may influence disease progression and mortality, yet their role in the CKM syndrome population remains underexplored.
To evaluate potential associations of the dietary inflammatory index (DII), the dietary oxidative balance score (DOBS), and mortality in individuals with CKM syndrome.
A total of 17,317 individuals with CKM syndrome were enrolled and stratified into three groups: stage 0, stages 1-3, and stage 4. DII and DOBS were derived from 26 and 16 preselected dietary components, respectively. Kaplan-Meier analysis, Cox proportional-hazards models, and forest plots were used to examine the associations between dietary scores and mortality across CKM stages.
No significant associations were found in stage 0. In stages 1-3 and 4, pro-inflammatory/pro-oxidant diets were associated with increased mortality, with HRs for all-cause, cardiovascular, and non-cardiovascular mortality of 1.46 (1.10-1.94), 1.42 (0.70-2.87), and 1.47 (1.09-1.98) in stages 1-3, and 2.07 (1.33-3.20), 2.20 (1.06-4.59), and 2.01 (1.25-3.24) in stage 4, respectively.
Pro-inflammatory and pro-oxidant dietary patterns, as measured by DII and DOBS, are associated with an increased risk of all-cause and non-cardiovascular mortality in both CKM stages 1-3 and stage 4, and with cardiovascular mortality specifically in stage 4. No significant association with cardiovascular mortality was observed in stages 1-3.

PMID:
42608635
Bibliographic data and abstract were imported from PubMed on 18 Aug 2026.

Read full publication at:
Please sign in to see all details.

Stats

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.