Authors
Ryota Sato
Published in
Brain and nerve = Shinkei kenkyu no shinpo. Volume 78. Issue 8. Pages 875-882.
Abstract
The peripheral autonomic nervous system predominantly comprises unmyelinated fibers, which are difficult to evaluate using conventional light microscopy. Historically, morphological assessment of unmyelinated fibers relied on the electron microscopy of sural nerve biopsy specimens, which is a technically demanding approach with limited accessibility to autonomic structures. Skin biopsy with immunohistochemical staining for the pan-axonal marker PGP 9.5 has enabled minimally invasive and quantitative evaluation of somatic small (intraepidermal nerve fiber density) and autonomic fibers innervating sweat glands, arrector pili muscles, and dermal vasculature. An integrated analysis combining autopsy findings, sural nerve biopsy, and skin biopsy may clarify the pathophysiology of peripheral autonomic neuropathy.
PMID:
42609144
Bibliographic data and abstract were imported from PubMed on 18 Aug 2026.
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