Authors
Molly K Paul, Sarah E Szakas, Cyril V Thompson, Jordan S Stanberry, Spencer M Scott, Rachel A Bergin, Brian W Ticknor, Hunter B Andrews, Benjamin T Manard
Published in
Analytical chemistry. Volume 98. Issue 32. Pages 23774-23783. Aug 18, 2026.
Abstract
-Nanotechnology is a salient part of the scientific landscape, and analytical approaches are rapidly evolving to enable small-scale characterization of nano- and microparticle compositions and impurities. Here, a flow-through sonicating cell was developed for direct particle extraction from a silicon wafer and integrated with an inductively coupled plasma-mass spectrometer (ICP-MS) for subsequent elemental and isotopic characterization of the released particles. Ultrasonic extraction (UE)─single particle (SP)─ICP-MS offers controlled particle mobilization from solid substrates and allows for increased sample throughput by eliminating the need for pre-extraction of particles and decreasing sample preparation steps. Coupling this device to an ICP-MS with a time-of-flight (TOF) mass analyzer, it is possible to distinguish unique isotopic compositions of the particles. Both tungsten and nickel isotopically tagged particles, which were deposited on Si wafers, are presented here with analysis via UE─SP─ICP-MS. This approach could support efforts in the fields of particle synthesis, nuclear safeguards and forensics, environmental monitoring, and semiconductor industries in which the detection of particles from substrates and wafers is critical.
PMID:
42610915
Bibliographic data and abstract were imported from PubMed on 18 Aug 2026.
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