European Standard Clinical Practice Recommendations for Olfactory Neuroblastoma in Children and Adolescents: An Updated Consensus by the Expert Group.

Authors

Daniela Di Carlo, Giulia Fichera, Benoit Dumont, Enrico Pozzo, Beate Timmermann, Romain Luscan, Antoine Moya-Plana, Anna Synakiewicz, Ewa Bien, Malgorzata A Krawczyk, Nuno Jorge do Reis Farinha, Rita Alaggio, Apostolos Pourtsidis, Brice Fresneau, Yves Reguerre, Tal Ben-Ami, Calogero Virgone, Jelena Roganovic, Jan Godzinski, Ines Brecht, Dominik T Schneider, Andrea Ferrari, Barbara Hero, Rajkumar Venkatramani, Elisabetta Zanoletti, Marco Ferrari, Daniel Orbach, Gianni Bisogno

Published in

Pediatric blood & cancer. Pages e70527. Aug 18, 2026. Epub Aug 18, 2026.

Abstract

Pediatric very rare tumors (VRTs) are a highly heterogeneous group of neoplasms defined by an annual incidence of <2 cases per million children under 18 years. Their rarity precludes prospective clinical trials, resulting in limited evidence-based guidelines and largely individualized treatment approaches. Olfactory neuroblastoma (ON) is an exceptionally rare pediatric VRT arising from the olfactory neuroepithelium, typically affecting adults. In children, ON is locally aggressive and may present with regional or distant metastases. Prognosis depends on stage, histology, and multimodal treatment. Owing to the absence of pediatric-specific guidelines, this project aims to develop internationally harmonized consensus recommendations for diagnosis and management.

PMID:
42610392
Bibliographic data and abstract were imported from PubMed on 18 Aug 2026.

Read full publication at:
Please sign in to see all details.

Stats

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.