Single-atom catalysts boost radical-mediated organic synthesis.

Authors

Meiqi Zhu, Dingyi Wang, Zezhao Li, Yuqing Liu, Xin-Yu Wang, Tianyou Zhao, Chang-Jie Yang, Jiarui Yang, Xinqiang Wang, Wen-Gang Cui, Hongge Pan, Dingsheng Wang, Wen-Hao Li

Published in

Chemical Society reviews. Aug 18, 2026. Epub Aug 18, 2026.

Abstract

Radical-mediated organic synthesis offers mild and sustainable routes to complex molecules, but conventional metal catalysts often suffer from limited activity, selectivity and recyclability. Single-atom catalysts, featuring atomically dispersed metal centres and well-defined coordination environments, provide an efficient platform for single-electron transfer, radical generation and intermediate stabilisation. This review summarises recent advances in single-atom-catalysed radical transformations, with emphasis on catalyst design, characterisation and mechanistic insight, and outlines key challenges and opportunities for developing sustainable radical methodologies based on single-atom catalysis.

PMID:
42610568
Bibliographic data and abstract were imported from PubMed on 18 Aug 2026.

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