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Trojan mast cells: repurposing allergy for targeted oncolytic delivery.

Created on 19 Aug 2026

Authors

Mengqin Guo, Wenhao Wang, Zhengwei Huang

Published in

Trends in pharmacological sciences. Aug 18, 2026. Epub Aug 18, 2026.

Abstract

Oncolytic viruses hold immense therapeutic promise but face formidable systemic delivery barriers. A new study by Xu et al. engineered immunoglobulin E-sensitized mast cells to selectively ferry these viruses into tumors. Excitingly, antigen-triggered degranulation precisely releases the viral payload and reshapes the immune microenvironment, offering a highly modular delivery paradigm.

PMID:
42613295
Bibliographic data and abstract were imported from PubMed on 19 Aug 2026.

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