Subcellular proteomic analysis of the DDR2 interactome in a neuronal cell model exposed to Aβ42.

Authors

Russa Das, Debashis Mukhopadhyay

Published in

Biochimica et biophysica acta. Proteins and proteomics. Pages 141173. Aug 18, 2026. Epub Aug 18, 2026.

Abstract

Receptor tyrosine kinases (RTKs) are increasingly understood to signal beyond the plasma membrane. However, the role of Discoidin domain receptor 2 (DDR2), which is activated by collagen, in neurodegeneration remains poorly understood. This study uses immunoprecipitation followed by mass spectrometry on cytoplasmic and nuclear fractions from a neuronal cell model to show that Aβ₄₂ exposure is associated with a compartment-specific reorganization of DDR2-associated protein complexes, characterized by increased nuclear representation. This reveals a unique nuclear DDR2 interactome under amyloidogenic conditions. By exploring this non-canonical, compartment-specific DDR2 signaling pathway, our results offer new insights into how receptor signaling networks may be altered in Alzheimer's disease pathology. Additionally, we identify DDR2-related nuclear interactions as potential sites of dysregulation in neurodegeneration.

PMID:
42612957
Bibliographic data and abstract were imported from PubMed on 19 Aug 2026.

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