Biological aging and the hidden architecture of early-onset cancer risk.

Authors

Ammal Abbasi, Ludmil B Alexandrov

Published in

Cancer cell. Aug 18, 2026. Epub Aug 18, 2026.

Abstract

In a Nature Medicine study, Tian et al. identify larger biological age gaps associated with early-onset lung, colorectal, and uterine cancers across birth cohorts. These findings position biological age as an integrative marker of physiological dysregulation. Future work combining aging clocks and mutational signatures could distinguish tumor-promoting states from tumor-initiating exposures.

PMID:
42612635
Bibliographic data and abstract were imported from PubMed on 19 Aug 2026.

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