POEMS syndrome with atypical presentation: A rare case.

Authors

S Singhal, M M Bharath, R Verma, V K Paliwal

Published in

Journal of postgraduate medicine. Aug 10, 2026. Epub Aug 10, 2026.

Abstract

POEMS is an uncommon paraneoplastic plasma cell disorder known with the expansion of polyneuropathy, organomegaly, endocrine abnormalities, M-band, and skin changes. We report a patient presenting with monoarthritis and weight loss for 5 months, who was treated empirically for tuberculous arthritis and later developed debilitating axonal polyneuropathy due to delayed diagnosis. POEMS/Plasma cell dyscrasias rarely involve joints, and this case highlights this unique presentation of POEMS syndrome. Bone biopsy from the affected joint revealed the diagnosis. Chronic large-joint monoarthritis with systemic symptoms, mimicking tuberculous arthritis, and polyneuropathy is a unique combination-so clinicians should consider an underlying plasma cell dyscrasia/POEMS to avoid delayed diagnosis.

PMID:
42616910
Bibliographic data and abstract were imported from PubMed on 20 Aug 2026.

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