Authors
Anne Mlocek, Nadine Dietze-Jergus, Norman Lippmann, Gunter Matthias Christian Flemming, Jürgen Feisthammel, Albrecht Hoffmeister, Christoph Lübbert
Published in
Zeitschrift fur Gastroenterologie. Aug 19, 2026. Epub Aug 19, 2026.
Abstract
Rising antibiotic resistance (particularly to clarithromycin and levofloxacin) is reducing eradication rates for Helicobacter (H.) pylori infections.
To establish and evaluate a routine microbiological procedure for H. pylori resistance testing at Leipzig University Medical Center in order to assess local resistance epidemiology, optimize resistance-adapted eradication therapies, and support an antibiotic stewardship approach.
Prospective, single-center observational study including adults, children, and adolescents. Biopsies from the antrum and corpus obtained during outpatient gastroscopies were cultured microbiologically (phenotypic resistance testing) and examined using specific PCR (molecular genetic detection).
From 2017 to 2020, biopsies from 260 adults and 81 children were analyzed. Cultural detection was more frequent in children (19.8 % vs. 8.8 %, p = 0.007); a total of 39 H. pylori strains were isolated. Resistance was observed against metronidazole (40 %), clarithromycin (12 %), and levofloxacin (8 %). Clarithromycin resistance mutations (23S rRNA gene) were present in 5 % of adults and 16.7 % of children. Cultivation took 10 days, and resistance testing took an additional 4 days.
Systematic H. pylori resistance testing is clinically useful. However, routine laboratory culture is subject to limitations in daily practice and requires significant effort.
PMID:
42618011
Bibliographic data and abstract were imported from PubMed on 20 Aug 2026.
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