Infliximab-associated sarcoid-like reaction and haemophagocytic lymphohistiocytosis in multisystem sarcoidosis.

Authors

Indira Acharya, Onyekachi C Ibe-Ejiogu, Ashik Pokharel, Palapun Waitayangkoon, Kevin D Kerin, Scott A Pompa, Christopher M Burns

Published in

BMJ case reports. Volume 19. Issue 8. Aug 19, 2026. Epub Aug 19, 2026.

Abstract

Drug-associated sarcoidosis-like reactions and drug-associated haemophagocytic lymphohistiocytosis (HLH) are rare immune-mediated complications, each associated with significant diagnostic and therapeutic challenges. We report a man with multisystem sarcoidosis who developed concurrent drug-associated sarcoid-like reaction and secondary HLH following initiation of infliximab therapy. The diagnosis was supported by characteristic imaging findings, laboratory evidence of hyperinflammation and a clear temporal relationship to infliximab exposure, with clinical improvement after drug discontinuation and immunosuppressive therapy.

PMID:
42618309
Bibliographic data and abstract were imported from PubMed on 20 Aug 2026.

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