Arachnoid granulation morphologies and β-amyloid and tau pathology in older adults.

Authors

Rashi I Mehta, Tianhao Wang, Aubrey Lewis, Claire E Walker, Caroline Gebczak, Lisa L Barnes, David A Bennett, Rupal I Mehta

Published in

Alzheimer's & dementia : the journal of the Alzheimer's Association. Volume 22. Issue 8. Pages e71736.

Abstract

Arachnoid granulations (AG) prominently enlarge with age, yet limited studies evaluate AG in neurodegeneration. Here, we investigate the associations of AG morphologies with Alzheimer's disease (AD).
Macroscopic AG properties were evaluated along dorsal post mortem brain specimens (n = 882). Regression models were used to analyze their associations with AD neuropathology and dementia, adjusting for demographics.
Participants died at mean age of 90.62 (SD = 6.98) years. β-amyloid (odds ratio [OR], 0.79 [95% confidence interval {CI}, 0.66-0.95]) and neurofibrillary tangles (OR, 0.84 [95% CI, 0.71-0.98]) inversely associated with AG count. β-amyloid (OR, 0.78 [95% CI, 0.65-0.92]) and B (Braak) score (OR, 0.80 [95% CI, 0.66-0.96]) inversely associated with AG patch count. Linear type AG in frontal (OR, 1.46 [95% CI, 1.03-2.07]) and parietal (OR, 1.57 [95% CI, 1.02-2.43]) regions was associated with higher odds of dementia.
Select AG morphologic properties associate with AD outcomes. Future studies should explore mechanisms underlying these associations.

PMID:
42619370
Bibliographic data and abstract were imported from PubMed on 20 Aug 2026.

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