BRIDGE-2M: Optimizing Bridging Therapy Prior to CAR-T Therapy in Multiple Myeloma: A Modified Double-Blind Delphi Panel of US Physicians.

Authors

Rahul Banerjee, Hamza Hashmi, Preet M Chaudhary, Shebli Atrash, Kimberly Green, Sabyasachi Ghosh, Todd Bixby, Denise De Wiest, Matthew Perciavalle, David H Vesole, Forat Lutfi, Waqas Jehangir, Gurbakhash Kaur, Adeel M Khan, Rahma Warsame, Ashwathi Puravankara Menon, Mark A Price, Guru Subramanian Murthy, Danai Dima, Brian J Carney, Zaina P Qureshi, Saurabh Chhabra

Published in

Advances in therapy. Aug 19, 2026. Epub Aug 19, 2026.

Abstract

We aimed to achieve consensus on optimal bridging therapy (BT) selection for patients with relapsed/refractory multiple myeloma (RRMM) undergoing chimeric antigen receptor T-cell (CAR-T) therapy.
We conducted a double-blind, three-round modified Delphi panel among U.S.-based hematologist-oncologists/hematologists using CAR-T therapy for RRMM.
Panelists (N = 15; all managing -60-100 patients with RRMM within the past year; > 5 years of practice: 86.7%) reached consensus on key attributes influencing BT selection (disease burden, aggressive disease, performance status, comorbidities, line of therapy, age, frailty). Unique patient attributes were linked to clinical objectives (≥ 65 years or frailty: disease stabilization [71% consensus]; poor performance status: end-organ function preservation; comorbidities: functional preservation; high disease burden: preventing clinical decline; aggressive disease: cytoreduction [all 100% consensus]). Goals of BT were to decrease disease burden and promote CAR-T efficacy and safety (100% consensus). While talquetamab was preferred for bridging in later lines (66.7%), 73.3% would consider earlier-line use if approved.
This study synthesized expert physician perspectives to develop a consensus-based framework to optimize BT selection, linking five key patient attributes to clinical objectives, with goals extending beyond disease stabilization to enhancing CAR-T efficacy and safety. Graphical abstract available for this article 10.6084/m9.figshare.33016328.

PMID:
42618714
Bibliographic data and abstract were imported from PubMed on 20 Aug 2026.

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