Authors
Célia Paulmin, Bérengère Koehl, Audrey Maudoux, Hanine Mansour, Marie-Hélène Odievre, Nathalie Garrec, Emilie Georget, Cécile Arnaud, Slimane Allali, Lydia Doumdo, Marie Belloy, Corinne Guitton
Published in
Pediatric blood & cancer. Pages e70605. Aug 20, 2026. Epub Aug 20, 2026.
Abstract
Neurological manifestations in children with hemoglobin SC (HbSC) disease remain insufficiently characterized, particularly regarding acute events. The aim of this study was to describe the spectrum and frequency of acute neurological events in a multicenter cohort of children with HbSC disease.
We conducted a retrospective descriptive multicenter study including children with HbSC disease aged 0-18 years who presented with at least one acute neurological event between January 1, 2010, and August 31, 2023, in Île-de-France, Martinique, and Guadeloupe.
Twenty-five patients from 10 centers were included. A total of 34 acute neurological events were recorded. Neuro-ENT (ear, nose, throat) manifestations were the most frequent (41%), including vestibular syndromes and sudden hearing loss, followed by central neurological deficits or altered consciousness (18%), seizures (18%), acute headaches (18%), and peripheral neuropathies (6%). Neuro-ENT manifestations showed recurrence in some patients. Cerebrovascular events occurred across all age groups and were observed in patients with a history of vaso-occlusive crises.
Acute neurological events may occur in children with HbSC disease and show a heterogeneous clinical spectrum. Further studies are needed to better characterize their determinants and clinical significance.
Not applicable.
PMID:
42622377
Bibliographic data and abstract were imported from PubMed on 20 Aug 2026.
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