ACETABULAR DYSPLASIA TRAJECTORIES DURING GROWTH FROM 6 TO 18 YEARS.

Authors

N Hendriks, Z Zheng, F Boel, F Rivadeneira, C J Tiderius, S M A Bierma-Zeinstra, R Agricola, J Runhaar

Published in

Osteoarthritis imaging. Volume 6 Suppl 1. Pages 100428.

Abstract

Acetabular dysplasia (AD) is an important risk factor for early onset hip OA in relatively young individuals. AD is defined using various hip morphology measures. However, the developmental course of these measures from childhood to adulthood remains unclear. Understanding their longitudinal patterns is therefore essential.
To describe the longitudinal course of certain validated AD measures and to identify distinct trajectories of these measures.
Data from the population-based Generation R Study were used. Participants were examined around age 6, 9, 13 and 18 years. Participants with high-resolution anteroposterior (AP) dual-energy x-ray absorptiometry (DXA) of the right hip and AP full-body DXA were included. In total, 6332 participants were included (3107 males and 3225 females). Hip shape was outlined with radiological landmarks used to calculate the lateral center edge angle (LCEA; indicator of acetabular coverage), and the acetabular depth-width ratio (ADR; quantifying acetabular depth). The course of LCEA and ADR was assessed using all available data. Latent class growth analysis (LCGA) was used to identify trajectories, including participants with at least two measurements.
Both LCEA and ADR increased from ages 6 to 18, reaching mean values of 29.9° (SD 5.8) for LCEA and 326.4 (SD 31.8) for ADR. In both measures the largest increase was between 9 and 13 years. Table 1 shows all the mean values and SDs of each AD measure for all time points for males and females separately. In the LCGA, 3868 participants were included. No significant trajectories were identified for LCEA. For ADR, a quadratic two-class model best fit the data in both sexes. In males, mean ADR at age 18 was 380.4 (SD 23.3) in the trajectory with highest increase (Class 1, n = 199), and 317.0 (SD 26.0) in the other trajectory (Class 2, n = 1728). In females, corresponding values were 353.4 (SD 20.5) in the trajectory with highest increase (Class 1, n = 808), and 310.3 (SD 22.0) in the other trajectory (Class 2, n = 1321) (Figure 1).
This study describes the longitudinal course of the LCEA and ADR from childhood to early adulthood. While no distinct LCEA trajectories were observed, two ADR trajectories were identified in both sexes, mainly differing in acetabular depth at age 18. The smaller classes showed a deeper acetabulum during growth. Lower ADR values, indicating a shallower acetabulum, and are associated with AD. Understanding of acetabular development may support earlier identification of individuals at risk for AD-related hip OA.

PMID:
42622159
Bibliographic data and abstract were imported from PubMed on 20 Aug 2026.

Read full publication at:
Please sign in to see all details.

Stats

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.