Antibacterial phenolic compounds target GMPS from the endophytic Chaetomium grande-JPT2.

Authors

Wen Li, Shuqi Li, Mei Wang, Peng Zhang, Kangwen Xu, Donglin Zhao, Wenjun Li

Published in

Natural product research. Pages 1-11. Aug 20, 2026. Epub Aug 20, 2026.

Abstract

Plant bacterial diseases threaten global food security and agricultural product quality. This study aimed to explore natural products with anti-phytopathogenic bacterial activity towards the new target guanosine monophosphate synthase (GMPS). Twelve phenolic compounds, including a new one, peniquinone L (1), were isolated using column chromatography and semipreparative HPLC from Chaetomium grande-JPT2. The molecular structures of the isolated compounds were determined by HRESIMS, 1D and 2D NMR spectrometry. High-throughput activity screening revealed that compound 11 could inhibit GMPS, yielding an EC₅₀ value of 58.83 μg/mL. Molecular docking further revealed that the binding interaction between 11 and GMPS was primarily stabilised by two hydrogen bonds formed between the hydroxyl group in 11 and amino acid residues in GMPS. This is the first report on GMPS inhibition by phenolic compounds. Furthermore, compounds 4 and 7 displayed antibacterial activity against Xanthomonas axonopodis by two-fold serial dilution method, with MIC values of 100 μg/mL.

PMID:
42623608
Bibliographic data and abstract were imported from PubMed on 21 Aug 2026.

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