Innovations in Aptamer Technology: SELEX To Intelligent Molecular Engineering and Clinical Translation.

Authors

Arshad Mehmood, Miraj Ud Din, Sunil Kumar Shah, Muhammad Faizan Munawer, Munazzah Marryum, Hui Jiang, Xiaohui Liu, Xuemei Wang

Published in

FASEB journal : official publication of the Federation of American Societies for Experimental Biology. Volume 40. Issue 16. Pages e72237. Aug 31, 2026.

Abstract

Aptamers-short, single-stranded nucleic acids capable of folding into complex three-dimensional structures-have evolved from biochemical curiosities into programmable molecular interfaces with expanding diagnostic and therapeutic relevance. Through systematic evolution of ligands by exponential enrichment (SELEX), aptamers exploit the structural plasticity of nucleic acids to achieve high-affinity and high-specificity target recognition. Innovations in chemical modification, high-throughput sequencing, microfluidics, nanotechnology, and artificial intelligence (AI) have redefined aptamer discovery and translational potential. Aptamers transition from antibody alternatives to programmable molecular systems capable of sensing, computation, and controlled actuation in biological environments.

PMID:
42623114
Bibliographic data and abstract were imported from PubMed on 21 Aug 2026.

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