No staining needed: reading kidney injury by its own light.

Authors

Barbara Mara Klinkhammer, Christos Chatziantoniou

Published in

Kidney international. Volume 110. Issue 3. Pages 526-528.

Abstract

Proximal cells are the metabolically most active cells in the kidney and play a central role in driving kidney disease. Matsumoto et al. demonstrate that label-free near-infrared autofluorescence can visualize tubular injury in vivo by detecting coproporphyrin III accumulation caused by mitochondrial oxidative stress. The signal correlates with injury severity and treatment response in multiple mouse models and human samples, suggesting a promising biomarker for preclinical monitoring and potential clinical translation.

PMID:
42624540
Bibliographic data and abstract were imported from PubMed on 21 Aug 2026.

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