Evaluation of the impact of deltamethrin, dapagliflozin, and KB-R7943 on I_Na in HL-1 atrial myocytes and U2OS osteosarcoma cells: An investigative study.

Authors

Sheng-Che Lin, Yang-Kao Wang, Sheng-Nan Wu, Edmund Cheung So

Published in

Environmental toxicology and pharmacology. Pages 105133. Aug 20, 2026. Epub Aug 20, 2026.

Abstract

The effects of deltamethrin (DLT), alone or in combination with dapagliflozin (Dapa) or KB-R7943, on I_Na were investigated in HL-1 cardiomyocyte and U2OS osteosarcoma cells. DLT increased both transient I_Na (I_Na(T)) and tail I_Na in HL-1 cells. DLT exposure enhanced the persistent I_Na (I_Na(P)) in simulated mouse or guinea-pig ventricular action potentials (APs) while co-treatment of Dapa or KB-R7943 attenuated it. DLT altered the repolarization phase of simulated mouse ventricular APs, reversing the negative-slope conductance of I_Na(P) to positive and was subsequently ameliorated by Dapa. In guinea-pig ventricular Aps, DLT increases I_Na(P) while co-treatment with KB-R7943 attenuated it. U2OS cells displayed measurable I_Na to brief depolarizing pulses, and was significantly enhanced by DLT. Application of either Dapa or KB-R7943 effectively reversed this DLT-induced increase in I_Na amplitude. Our findings show that DLT exerts a stimulatory effect on I_Na in both cardiac and osteoblastic cells, while Dapa and KB-R7943 counteracted it.

PMID:
42624342
Bibliographic data and abstract were imported from PubMed on 21 Aug 2026.

Read full publication at:
Please sign in to see all details.

Stats

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.