Tumor cells recruit macrophage bodyguards to outlast chemotherapy.

Authors

Yuzhao Wang, Zibin Chen, Zhuowei Liu, Zikun Ma

Published in

Cancer cell. Aug 20, 2026. Epub Aug 20, 2026.

Abstract

In Cell Press Blue, Carvalho et al. identify spatially organized tumor-macrophage niches, EMT-like CD44^high cancer cells paired with SPP1/PARP14^high macrophages, that drive chemoresistance in bladder cancer. PARP14 inhibition can flip this protective niche into an inflammatory, cisplatin-sensitizing state.

PMID:
42624109
Bibliographic data and abstract were imported from PubMed on 21 Aug 2026.

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