HIF-1α sets the activation tempo of inflammatory macrophages.

Authors

Marta Manco, Alessia Zotta, Massimiliano Mazzone

Published in

Molecular cell. Volume 86. Issue 16. Pages 3119-3121. Aug 20, 2026.

Abstract

Hypoxia-inducible factor 1a (HIF-1α) sustains cell survival and metabolic adaptations under low-oxygen conditions and supports metabolic reprogramming of pro-inflammatory macrophages. In this issue of Molecular Cell, Davanzo and colleagues¹ uncover a HIF-1α-dependent biphasic regulatory program of macrophage activation in response to inflammatory cues and delineate its dynamic role in shaping antimicrobial defenses.

PMID:
42624079
Bibliographic data and abstract were imported from PubMed on 21 Aug 2026.

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