Interpreting p-tau217 on the ward: frailty and plasma biomarkers in acutely admitted older adults.

Authors

Jonas Goll, Ieva Martinaityte, Bjørn-Eivind Kirsebom, Dag Seeger Halvorsen, Fernando Gonzalez-Ortiz, Henrik Zetterberg, Tormod Fladby, Mona Dixon Gundersen

Published in

Alzheimer's & dementia : the journal of the Alzheimer's Association. Volume 22. Issue 8. Pages e71768.

Abstract

Older adults living with frailty are prone to adverse events upon acute hospitalization. Frailty biomarkers aiding early identification are lacking. This study explores frailty and Alzheimer's disease (AD)-related biomarkers.
Participants were recruited from the Norfrail study (n = 178) and from the Norwegian Dementia Disease Initiative (n = 105). Linear regression was used to analyze associations between frailty and the plasma biomarkers phosphorylated tau-217 (p-tau217), neurofilament light chain (NfL), brain-derived tau, ubiquitin carboxyl-terminal hydrolase L1, and glial fibrillary acidic protein in older adults admitted acutely to hospital.
No significant association was found between p-tau217 and frailty. Estimated glomerular filtration rate (eGFR) explained 27% of the variance of plasma p-tau217 (p < 0.001). NfL was the only biomarker significantly associated with frailty (p < 0.01).
Except for NfL, plasma biomarkers were independent of frailty. Substantial p-tau217 variability was explained by eGFR. Clinicians need to consider renal function when interpreting p-tau217 in unselected populations.

PMID:
42625502
Bibliographic data and abstract were imported from PubMed on 21 Aug 2026.

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