Authors
Hengzhou He, Yanyang Wang, Feihao Yao, Ying Huang, Yuan Jiang, Ning Jiang, Bo Geng, Bo Zeng
Published in
Mikrochimica acta. Volume 193. Issue 9. Aug 21, 2026. Epub Aug 21, 2026.
Abstract
Surface-enhanced Raman scattering (SERS) and surface-enhanced resonance Raman scattering (SERRS) offer molecular fingerprint specificity, high sensitivity, narrow spectral bandwidths, and multiplex readout capability for biosensing and biomedical analysis. In reporter-encoded SERS/SERRS nanotags, Raman reporters are key signal-generating molecules that define spectral identity, context-dependent brightness, stability, multiplexing capacity, and quantitative reliability. However, existing reviews have mainly focused on plasmonic substrates, nanotag architectures, assay formats, imaging applications, or spectral-analysis workflows, whereas reporter molecules themselves have been less systematically discussed as molecular and interfacial design variables. This review provides a focused, reporter-centered synthesis of conventional, aromatic thiol/disulfide, Raman-silent-region, near-infrared-resonant/SERRS, responsive, and library-based reporters. We discuss reporter selection principles, reporter-core interactions, immobilization chemistry, surface coverage and orientation, spectral orthogonality, responsive-reporter metrics, multiplex unmixing, machine-learning-assisted spectral decoding, biomolecular scaffolds, and whole-nanoprobe safety. By integrating molecular design, interfacial stability, quantitative performance evaluation, and translational constraints, this review aims to support rational Raman reporter selection, benchmarking, and application-specific deployment.
PMID:
42625097
Bibliographic data and abstract were imported from PubMed on 21 Aug 2026.
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