Dealing with membrane stress through CASM.

Authors

Håvard Styrkestad Haukaas, Sven R Carlsson, Alf Håkon Lystad

Published in

Autophagy. Pages 1-10. Aug 21, 2026. Epub Aug 21, 2026.

Abstract

Compartments of the endolysosomal and secretory pathways encounter diverse insults - from loss of ion gradients and osmotic imbalance to physical membrane disruption - creating a need for rapid, localized surveillance and response systems. Recent work demonstrates that conjugation of ATG8 to single membranes (CASM) provides such specificity via stress-responsive targeting mechanisms that recruit the ATG8 conjugation machinery through pathways distinct from macroautophagy/autophagy. Here, we review recent advances in how membrane stress is sensed, coupled to CASM initiation, and converted into downstream cellular responses.

PMID:
42627010
Bibliographic data and abstract were imported from PubMed on 21 Aug 2026.

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