Lanolin-derived bioactive fractions promote infected wound healing via synergistic anti-inflammatory and pro-survival effects.

Authors

Xinhai Wang, Pilin Huang, Baichen Xiong, Yuqing Wei, Xiaoxue Bai, Chenyu Zhang, Chaojun Wang, Yue Wu, Feng Feng, Haopeng Sun, Yao Chen

Published in

Natural product research. Pages 1-12. Aug 21, 2026. Epub Aug 21, 2026.

Abstract

Three active fractions (QS1, QS2, HC1) were isolated from lanolin by activity‑guided fractionation. They promoted proliferation, migration and cell cycle progression of keratinocytes and fibroblasts. HPLC‑Q‑TOF/MS identified 34 compounds, including ceramides and fatty acids. Mechanistically, the fractions suppressed TLR9/NF‑κB/NLRP3 inflammation in LPS‑stimulated keratinocytes and activated PI3K/Akt survival signalling in 5‑FU‑treated fibroblasts. In a S. aureus‑infected full‑thickness wound model, the fraction‑loaded hydrogel accelerated wound closure. These results reveal that lanolin‑derived bioactive fractions facilitate infected wound healing through synergistic anti‑inflammatory and pro‑survival mechanisms.

PMID:
42627931
Bibliographic data and abstract were imported from PubMed on 22 Aug 2026.

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