Authors
Arvind Chandna, Silvia Veitzman, Celine Kim, Mike Wong, Joseph Towler
Published in
PloS one. Volume 21. Issue 8. Pages e0354174. Epub Aug 21, 2026.
Abstract
Cerebral Visual Impairment (CVI) of early onset has primarily been studied in children, but little is known about its progression into adulthood, despite CVI being recognized as a lifelong condition. This study investigates higher visual function deficits (HVFDs) in adults with early-onset CVI through a prospective controlled design. We first assessed the feasibility of an adapted HVF Question Inventory (HVFQI-59Q) in detecting HVFDs in adults with CVI compared to neurotypical (NT) adults (ANTs, n = 67). We then compared HVFD patterns in adults with early-onset CVI (A-Early Onset, n = 29), adults with late-onset brain injury (A-Late Onset, n = 22), and a previously interviewed cohort of children with CVI (n = 92) and child neurotypicals (n = 120). The HVFQI-59Q was used to evaluate the spectrum and severity of HVFDs across the adult groups. Results showed HVFDs are present in A-Early Onset, with similarities and distinct differences compared to children. The A-Late Onset group exhibited a broader range of deficits and lower median values, suggesting more variability in visual impairments. These findings confirm that HVFDs persist into adulthood and that late-onset brain injuries may result in HVFDs similar to CVI, challenging previous assumptions about localized effects and the need for a review of terminology for A-Late Onset, highlighting the need for further research in the adult group. The study underscores the importance of continuous CVI evaluation across the lifespan and supports the HVFQI-59Q as an effective clinical tool for detecting HVFDs.
PMID:
42627858
Bibliographic data and abstract were imported from PubMed on 22 Aug 2026.
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