Vitamins tune cell death thresholds.

Authors

Rui Kang, Guido Kroemer, Daolin Tang

Published in

Trends in cell biology. Aug 21, 2026. Epub Aug 21, 2026.

Abstract

Vitamins are essential micronutrients traditionally viewed as passive cofactors that sustain cellular homeostasis. Emerging evidence challenges this notion, identifying vitamins as active regulators of cell fate that tune the threshold for regulated cell death. Through coordinated control of redox balance, metabolic pathways, and signaling networks, vitamins shape cellular susceptibility to diverse death programs. Their effects are highly context-dependent, enabling both prosurvival and prodeath outcomes depending on dose, cell type, and metabolic state. Recent studies further uncover noncanonical mechanisms linking vitamins to lipid remodeling, membrane trafficking, and organelle integrity. Collectively, these advances establish vitamins as dynamic modulators of cellular vulnerability and highlight their potential as therapeutic targets for selectively manipulating cell death in disease.

PMID:
42629301
Bibliographic data and abstract were imported from PubMed on 22 Aug 2026.

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