Authors
Hanxiao Zeng, Yaxing Wang, Chenmeng Huang, Rui Jiang, Yongfei Zhang, Zixue Chai, Jiangyang Chi, Yonghui Zhang, Zhengxi Hu
Published in
Chinese journal of natural medicines. Volume 24. Issue 9. Pages 1110-1122.
Abstract
Guided by molecular networking, HSQC-based DeepSAT, and SMART analyses, a chemical investigation of the coral-derived fungus Talaromyces sp. TJ403-AL05 led to the isolation and identification of taladipyrones A-I (1-9), a series of new α-pyrone dimers with four distinct skeletons. Among these, compounds 1 and 9 represented two unprecedented classes of rearranged α-pyrone dimers, and compounds 5-7 were the first talarolactone-type dimers obtained as racemates. Extensive spectroscopic analysis, quantum chemical calculations, and X-ray diffraction analysis were used to determine their structures, including each enantiomer of racemic compounds 5-8 after chiral HPLC resolution. In human cardiomyocytes (AC16), compounds 1-6 and 8-9 attenuated injury caused by 24 h cold ischemia (CI) at 40 µmol·L-1. Moreover, compound 2 could improve CI-induced disruption of redox homeostasis via activation of the PI3K/AKT signaling pathway, representing the first fungal polyketide with such cardioprotective activity.
PMID:
42629117
Bibliographic data and abstract were imported from PubMed on 22 Aug 2026.
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