Authors
Yumi Park, Young-Heon Shin, Yuan Yuan, Justin Y Jeon, Yiwen Zhang, Gerson Ferrari, Leandro F M Rezende, Edward L Giovannucci, Dong Hoon Lee
Published in
Diabetes research and clinical practice. Pages 113509. Aug 21, 2026. Epub Aug 21, 2026.
Abstract
We aimed to compare exercise modalities and evaluate dose-response relationships with glycemic control including continuous aerobic exercise (CAE), resistance training (RT), combined exercise (CE), mind-body exercise (MBE), and high-intensity interval training (HIIT) in older adults with type 2 diabetes mellitus (T2DM). Three databases were searched for randomized controlled trials of exercise interventions in older adults with T2DM reporting glycated hemoglobin (HbA1c). Pairwise, Bayesian network, and dose-response meta-analyses were conducted. Compared with control, HIIT demonstrated the largest estimated reduction (MD = - 0.95%; 95% CrI - 1.45, -0.49), followed by CE (MD = - 0.59%; 95% CrI - 0.93, -0.25), CAE (MD = - 0.46%; 95% CrI - 0.69, -0.24), MBE (MD = - 0.42%; 95% CrI - 0.76, -0.10), and RT (MD = - 0.29%; 95% CrI - 0.51, -0.08). Dose-response network meta-analyses suggested a non-linear association between overall exercise dose and HbA1c reduction, with maximal estimated benefits at approximately 704 METs-min/week with the 95% CrI excluding zero between 241 and 920 METs-min/week. HIIT demonstrated the steepest estimated dose-response relationship, but with wider credible intervals. Other exercise modalities showed more gradual dose-response patterns across their estimated effective ranges. Our findings suggest that exercise prescription for older adults with T2DM should be individualized according to exercise modality, dose, and health status.
PMID:
42628655
Bibliographic data and abstract were imported from PubMed on 22 Aug 2026.
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