Authors
Ziyan Lou, Xinze Han, Xiaomin Wu, Keran Duan, Xian Cai, Liping Zu, Lingyan Liu, Fei Ma
Published in
BMJ open. Volume 16. Issue 8. Pages e115914. Aug 21, 2026. Epub Aug 21, 2026.
Abstract
To explore the association between serum 25-hydroxyvitamin D (25-OH-D) levels and mild cognitive impairment (MCI) and further analyse the association between serum 25-OH-D levels and different dimensions of cognitive function.
Cross-sectional study.
Tianjin, China.
A total of 866 participants aged 65 and above were enrolled in this study.
MCI was diagnosed based on the revised Petersen diagnostic criteria. Cognitive function was assessed by the Wechsler Adult Intelligence Scale Revised in China.
The prevalence of MCI was 12.0%. Higher serum 25-OH-D levels were significantly associated with lower odds of MCI, as well as with MCI across all subgroups (p<0.05). Serum 25-OH-D levels were significantly and positively associated with full intelligence quotient (FIQ), verbal intelligence quotient (VIQ), information, similarity and vocabulary (p<0.05). The associations between serum 25-OH-D levels and cognitive function did not significantly differ by age, gender or education level, with no statistical evidence of interactive effects.
Higher serum 25-OH-D levels were significantly associated with lower odds of MCI. Furthermore, serum 25-OH-D levels were significantly and positively associated with different dimensions of cognitive function, specifically FIQ, VIQ, information, similarity and vocabulary. There was no statistically significant interaction observed between serum 25-OH-D levels and age, gender or education level.
PMID:
42629155
Bibliographic data and abstract were imported from PubMed on 22 Aug 2026.
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