Reliable One-Pot Automated Preparation of [¹¹C]SL25.1188 for Use in Clinical Imaging Studies.

Authors

Hiroki Hashimoto, Takayuki Ohkubo, Kaito Tsukagoe, Tomoya Fujishiro, Daisuke Arashi, Tatsuto Sato, Takeru Seki, Yusuke Kurihara, Masanao Ogawa, Masatoshi Muto, Nobuki Nengaki, Wakana Mori, Masayuki Fujinaga, Kazunori Kawamura, Ming-Rong Zhang

Published in

Journal of labelled compounds & radiopharmaceuticals. Volume 69. Issue 10-11. Pages e70035.

Abstract

We clinically investigated (S)-5-methoxymethyl-3-[6-(4,4,4-trifluorobutoxy)benzo[d]isoxazol-3-yl]oxazolidin-2-[¹¹C]-one ([¹¹C]SL25.1188) as a positron emission tomography tracer for imaging monoamine oxidase B. To perform clinical imaging studies at our institute, we established a routine method for preparing the [¹¹C]SL25.1188 injection using a one-pot [¹¹C]CO₂ fixation method. We successfully prepared the [¹¹C]SL25.1188 injection using a ¹¹C-labeling synthesizer and sterile isolator. The radiosynthesis time and decay-corrected radiochemical yield based on [¹¹C]CO₂ were below 30 min and 49% ± 10% postirradiation (n = 104), respectively. At the end of synthesis (n = 104), the molar activity was 180 ± 57 GBq/μmol, and the radiochemical purity exceeded 99%. The results of [¹¹C]SL25.1188 injection complied fully with our in-house quality control and quality assurance criteria, confirming a reliable supply of high-quality [¹¹C]SL25.1188 formulation with adequate radioactivity for use in clinical imaging studies.

PMID:
42629317
Bibliographic data and abstract were imported from PubMed on 22 Aug 2026.

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