Genomic analysis of two Leisingera strains SA32 and SA215 reveals their distinct roles in marine sulfur cycling.

Authors

Kang He, Suyun Fang, Pengyu Wang, Qing Liu, Xiaoke Hu

Published in

Marine genomics. Volume 87. Pages 101250. Sep 30, 2026. Epub Jun 04, 2026.

Abstract

As a key marine organic sulfur compound, dimethylsulfoniopropionate (DMSP) is an important carbon and sulfur source for marine microorganisms and the primary precursor of dimethyl sulfide (DMS). The metabolism of DMSP by marine bacteria regulates the air-sea flux of DMS, thereby affecting the global climate. This study reports the genomic features of two Leisingera strains (SA32 and SA215) isolated from marine environments, with an emphasis on genes involved in sulfur metabolism. The genome of strain SA32 is 4,678,260 bp with a GC content of 63.48%, while that of strain SA215 is 4,754,962 bp with a GC content of 62.27%. Genomic analysis shows that both Leisingera strains contain genes encoding DMSP lyases; however, strain SA32 only possesses a DMSP cleavage pathway centered on DddD, while strain SA215 has both a complete DMSP demethylation pathway (involving DmdA, DmdB, DmdC, and DmdD) and cleavage pathways mediated by DddQ, DddP, and DddD, indicating a greater capacity for utilizing marine organic sulfur. This study highlights the functional differentiation of DMSP metabolism in the two marine Leisingera strains, deepening our understanding of the ecological roles of this genus in the marine sulfur cycle.

PMID:
42629104
Bibliographic data and abstract were imported from PubMed on 22 Aug 2026.

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