Structural programmability of jujube polysaccharides: Extraction, molecular architecture, and microbiota-mediated fermentation Design for gut-Brain-Axis-Relevant Applications.

Authors

Fengling Liu, Zhihui Luo, Sidra Jabeen, Gang Liu, Pan Li, Tao Wu, Weili Li

Published in

Food research international (Ottawa, Ont.). Volume 242. Issue Pt 1. Pages 119833. Oct 31, 2026. Epub Jun 23, 2026.

Abstract

Jujube polysaccharides (JPs) are heterogeneous food pectic glycans, but how extraction and post-isolation modification define their molecular architecture and microbiota-accessible functionality remains insufficiently integrated. This review critically synthesizes evidence linking extraction conditions to JP structural templates and evaluates how post-isolation remodeling tunes molecular weight, RG-I/HG balance, side-chain architecture, esterification, charge, conformation, and assembly state. Using an evidence-stratified framework, we distinguish direct JP findings from mechanisms inferred from broader pectin and dietary-fiber literature. We propose that backbone architecture, RG-I-associated side chains, esterification, and supramolecular organization may shape microbial accessibility, fermentation kinetics, selective utilization, short-chain fatty acid production, and gastrointestinal substrate availability. This structure-microbiota-metabolite perspective supports a validation pipeline based on defined JP fractions, matched pectin controls, standardized fermentation models, and causal microbiome designs. Gut-brain-axis relevance is discussed as an indirect, evidence-limited downstream implication rather than an established JP mechanism.

PMID:
42629065
Bibliographic data and abstract were imported from PubMed on 22 Aug 2026.

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