Clavukellines A-N: dolabellane diterpenes from the soft coral Clavulariakoellikeri.

Authors

Zhongyu Lu, Xiao Zhu, Xin Zhou, Xiaobin Li, Xiao Han, Guoqiang Li

Published in

Chinese journal of natural medicines. Volume 24. Issue 9. Pages 1123-1128.

Abstract

Chemical investigation of the soft coral Clavularia koellikeri led to the isolation of fourteen new diterpenoid derivatives clavukellines A-N (1-14) featuring the dolabellane-type skeleton. Structural characterization of these compounds was accomplished through an integrated analytical strategy combining NMR spectroscopy and HR-ESI-MS. Absolute configurations were unambiguously assigned using ECD spectral simulation and DP4 + probability analysis. Preliminary pharmacological evaluation indicated that compounds 8 and 13 exhibited anti-inflammatory activity, while compounds 1-14 showed antithrombotic activity. This study reveals promising anti-inflammatory and antithrombotic potentials that warrant further investigation.

PMID:
42629118
Bibliographic data and abstract were imported from PubMed on 22 Aug 2026.

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