Authors
Lie Li, Chengmei Li, Yubin Zhao, Yu Zhang, Qi Zhang, Peilu Huang, Lidong Deng, Qiyan Li, Ruiyuan Liu
Published in
Advanced healthcare materials. Pages e71645. Aug 21, 2026. Epub Aug 21, 2026.
Abstract
The development of organic photocatalysts holds considerable promise for the oxidation of NADH, thereby disrupting the NADH/NAD+ equilibrium, modulating redox homeostasis, and enhancing treatment of hypoxic tumors. However, there is still a lack of organic photocatalyst which could respond to near-infrared light. Herein, we develop an NIR-triggered organic photocatalyst (TTH) that produces hydroxyl radical and photooxidates NADH. Upon 808 nm light irradiation, TTH not only could generate hydroxyl radical in an optimized pathway of O2→O2 • -→H2O2→•OH and achieve effective oxidation of NADH and the reduction of cytochrome c, but also produces hyperthermia, facilitating NIR-II fluorescence-guided phototherapy of tumors. Moreover, TTH preferentially degrades glutathione, increases lipid peroxide levels, and downregulates glutathione peroxidase 4, culminating in mitochondrial dysfunction and the initiation of ferroptosis‑like cell death. Subsequently, the in vivo experiments proved that the photocatalytic TTH achieved antitumor efficacy in 4T1-bearing mouse models. Collectively, our research highlights the potential of employing an NIR-activated organic photocatalyst to integrate phototherapy with hydroxyl radical generation, representing a promising therapeutic strategy to disrupt intracellular redox homeostasis for the treatment of tumors.
PMID:
42629996
Bibliographic data and abstract were imported from PubMed on 22 Aug 2026.
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