The Diagnostic Value of Heparin-Binding Protein for Sepsis-Associated Acute Kidney Injury: A Retrospective Single-Center Study.

Authors

Yu Han, Wenna Ning, Jian Lu, Jinwei Zhu, Zhiliang Qin, Xiao Wang

Published in

International journal of general medicine. Volume 19. Pages 623797. Epub Aug 18, 2026.

Abstract

To explore the value of heparin-binding protein (HBP) in the diagnosis of sepsis-associated acute kidney injury (SA-AKI) in patients with sepsis.
This retrospective single-center study enrolled 114 patients with sepsis admitted between January 2023 and January 2025. Patients were divided into SA-AKI group (n=76) and non-SA-AKI group (n=38) based on the presence of AKI. Baseline clinical data were collected for both groups. Venous blood samples were obtained at ICU admission (within 30 minutes of arrival, T0) and at 24 h (T24), 48 h (T48), and 72 h (T72) thereafter for measurement of HBP and other infection-related biomarkers. General characteristics and dynamic changes in HBP levels were compared between the two groups. ROC curve analysis was performed to evaluate the diagnosticvalue of each biomarker for SA-AKI.
SOFA score, length of mechanical ventilation, and 28-day mortality were significantly higher in the SA-AKI group than in the non-SA-AKI group (all P < 0.05). HBP levels showed an increasing trend over time in the SA-AKI group, whereas a decreasing trend was observed in the non-SA-AKI group, with statistically significant differences between the two groups at all time points (P < 0.05). Levels of HBP, procalcitonin (PCT), and interleukin-6 (IL-6) were significantly higher in the SA-AKI group compared with the non-SA-AKI group (P < 0.05), while no significant differences were found in white blood cell count or C-reactive protein levels between the two groups. ROC curve analysis demonstrated that HBP, PCT, and IL-6 were effective predictors of SA-AKI, with AUC of 0.869 (95% CI 0.806-0.933, sensitivity 73.7%, specificity 86.8%), 0.777, and 0.738, respectively.
HBP demonstrates high early predictive value for SA-AKI in ICU patients with sepsis, with diagnostic performance superior to that of PCTand IL-6. HBP may serve as a promising early biomarker for the diagnosis of SA-AKI.

PMID:
42633362
Bibliographic data and abstract were imported from PubMed on 23 Aug 2026.

Read full publication at:
Please sign in to see all details.

Stats

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.