Zn-Ni metal-organic framework nanosheets@graphene oxide nanocomposite: A promising voltammetric platform for sensitive determination of doxorubicin.

Authors

Tahereh Kondori, Niloufar Akbarzadeh-T, Somayeh Tajik, Hadi Beitollahi

Published in

ADMET & DMPK. Volume 14. Pages 3384. Epub Jul 08, 2026.

Abstract

Doxorubicin (DOX) serves as an anthracycline-based chemotherapy drug to treat multiple types of cancers and sarcomas, which include lung, breast, bladder, leukaemia, liver, head and neck cancers.
The electroanalysis of the trace level of DOX in this study was conducted using a Zn-Ni metal-organic framework nanosheets@graphene oxide nanocomposite (Zn-Ni MOF NSs@GO) after the modification of a screen-printed carbon electrode (Zn-Ni MOF NSs@GO/SPCE). Using chronoamperometry, cyclic voltammetry and differential pulse voltammetry, the electrochemical characteristics of the sensor as constructed for DOX measurement were examined.
Consequently, the composite sensor demonstrated exceptional electrocatalytic performance in oxidizing DOX within a concentration range of 0.004 to 190.0 μM, with a detection limit of 0.001 μM. It was found that the Zn-Ni MOF NSs@GO/SPCE was effective at determining DOX in real samples, with good recovery values in the 97.1 to 102.0 % range.
The designed sensor with cost-effective and good performance could be valuable for therapeutic drug monitoring and clinical diagnostics.

PMID:
42633489
Bibliographic data and abstract were imported from PubMed on 23 Aug 2026.

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