LncRNA-driven alternative splicing landscapes associate with survival outcomes in ovarian cancer.

Authors

Yan Cao, Jian Zhao, Shan He, Qiong Wu, Yixuan Wang, Jing Wu, Jingjing Liu, Yuan Xie, Xiaofeng Song

Published in

Non-coding RNA research. Volume 20. Pages 113-122. Epub Aug 13, 2026.

Abstract

Ovarian cancer (OV) has the highest mortality rate among gynecological malignancies, with limited improvement in survival despite emerging treatments, underscoring an urgent need for novel diagnostic and therapeutic targets. Alternative splicing (AS) plays critical roles in OV progression, and long non-coding RNAs (lncRNAs) have recently been implicated as splicing regulators in tumor development. However, the landscape of lncRNA-mediated splicing dysregulation in OV remains unexplored. Here, we performed a genome-wide analysis integrating 207 differentially expressed lncRNAs and 1201 abnormal AS events from OV transcriptomes, identifying 2545 co-expression pairs. By constructing multi-layer regulatory networks incorporating splicing factors, transcription factors, and microRNAs, and applying a restart random walk algorithm seeded with oncogenes, we prioritized 29 hub splicing-regulatory lncRNAs, of which 15 are significantly associated with OV survival. This study provides novel lncRNA biomarkers and mechanistic insights into splicing dysregulation in OV.

PMID:
42633203
Bibliographic data and abstract were imported from PubMed on 23 Aug 2026.

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