Prevalence and features of eosinophilic gastrointestinal disorders using the large real-world TriNetX database.

Authors

Cora E Miracle, Noam Zevit, Edward Gerster, Kara Kliewer, Marc E Rothenberg

Published in

The journal of allergy and clinical immunology. Global. Volume 5. Issue 5. Pages 100762. Epub Jul 17, 2026.

Abstract

There are substantial questions concerning the epidemiology and demographics of eosinophilic gastrointestinal disorders (EGID). We queried TriNetX, a large electronic medical record database, to assess EGID demographics.
Our objective for this study was to characterize the prevalence, demographic features, disease overlap, and treatment patterns of patients with EGID using a large multicenter electronic health record database.
TriNetX, a deidentified patient database derived from 92 health care organizations and a total population of 129,260,452 patients, was queried for EGID. Cases were identified by ICD codes (eosinophilic esophagitis [EoE] K20, eosinophilic gastritis/enteritis [EoG/EoN] K52.81, eosinophilic colitis [EoC] K52.82) and endoscopy occurrence. Demographic and clinical characteristics were analyzed.
We identified 77,726 EoE, 6,554 EoG/EoN, and 2,898 EoC cases. Prevalence was approximately 1:1,673, 1:19,842, and 1:44,873, respectively. Multiple EGID occurred in 5% of all patients but in 47% of those with EoG/EoN. EGID was most common in non-Hispanic White individuals (79%). Male predominance was observed in EoE (59%) but not EoG/EoN (46%) or EoC (45%). Mean patient ages at query were 39, 31, and 40 years for EoE, EoG/EoN, and EoC, respectively (P < .0001). The most prescribed medications were proton pump inhibitors for EoE, antiemetics and corticosteroids for EoG/EoN, and corticosteroids for EoC.
We identified the largest reported population of patients with EGID (77,726 cases); our findings substantiate their rarity (0.002-0.5% prevalence), male predominance limited to EoE, substantial co-occurrence of multiple EGID, and distinct age distribution of EoG/EoN. The identified cohort and approaches provide opportunities for further research.

PMID:
42633198
Bibliographic data and abstract were imported from PubMed on 23 Aug 2026.

Read full publication at:
Please sign in to see all details.

Stats

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.