Protective effect and mechanism of SIRT1 under stress-induced vascular senescence.

Authors

Kexin Wang, Kejin Tang, Caixia Liu, Panpan Zhou, Wang He, Ying Xie, Changqing Deng

Published in

Open life sciences. Volume 21. Issue 1. Pages 20251366. Epub Aug 24, 2026.

Abstract

A major focus of contemporary medical research is the primary pathological cardiovascular diseases, whereas stress-induced vascular senescence is a process with degenerative changes in vascular morphology, structure, and function caused by oxidative stress (OS), inflammation, autophagy disorders, and other factors. Silent information regulator of transcription 1 (SIRT1), which may be a key gene linking oxidative stress and aging, has extensive biological functions in anti-oxidation, anti-inflammation, anti-apoptosis, and other aspects. This paper focuses on the protective effects and main mechanisms of SIRT1 on stress-induced vascular senescence and provides clues for preventing and treating diseases related to stress-induced vascular senescence.

PMID:
42633089
Bibliographic data and abstract were imported from PubMed on 23 Aug 2026.

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