An Essential Role of the AMPK-Related Kinase Snrk in Regulating Drosophila Sleep.

Authors

Weiwen Yang, Chaoyi Li, Jingyi Shi, Renbo Mao, Xinyue Xiong, Shichao Fan, Wenxia Zhang, Yi Rao

Published in

Genetics. Aug 23, 2026. Epub Aug 23, 2026.

Abstract

Protein kinases are important regulators of sleep in animals, but their loss-of-function mutations usually show moderate phenotypes. We report here that sucrose non-fermenting related kinase (Snrk), a member of the AMP-activated protein kinase-related kinase (ARK) family, plays an essential role in sleep regulation: snrk gene knockout resulted in a profound loss of night-time sleep phenotype, much stronger than that of the well-known ARK member sik3. This phenotype was completely rescued by neuronal Snrk expression. Snrk in adulthood was required for sleep. Catalytic and regulatory sites in Snrk were important for sleep. A chemoconnectomic (CCT) screen revealed Snrk functioning in cholinergic neurons whose activation is known to inhibit sleep. Sleep loss in snrk mutants was rescued by pharmacological blockade of nicotinic acetylcholine receptors. Our findings have uncovered a fundamental role for Snrk in cholinergic neurons to regulate sleep.

PMID:
42633704
Bibliographic data and abstract were imported from PubMed on 24 Aug 2026.

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