Electrochemical Detection Approaches Targeting Single Intact Virions.

Authors

Róbert E Gyurcsányi

Published in

Chimia. Volume 80. Issue 7-8. Pages 487-493. Aug 19, 2026. Epub Aug 19, 2026.

Abstract

Beyond emerging diagnostic applications, intact-virus detection is essential for understanding viral pathogenesis, host-pathogen interactions, and vaccine development. This review highlights in a timeline-based perspective the progress in electrochemical detection of intact virions, focusing on single-virion sensitivity. By directly probing intact viral particles rather than molecular surrogates, nanopore-based resistive-pulse sensing and nano-impact electrochemistry have emerged as versatile virus-counting strategies, enabling selective identification, quantitation, and characterization of morphological and chemical heterogeneity without ensemble averaging. Their potential for calibration-free quantitation, integration with microfluidics, in situ preconcentration, advanced signal processing, and artificial intelligence positions electrochemical platforms as powerful tools for virus analysis.

PMID:
42633628
Bibliographic data and abstract were imported from PubMed on 24 Aug 2026.

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