On-chip infrared metasurface glucose sensor based on asymmetric hook-shaped nanoantenna arrays.

Authors

Yuting Wen, Hengliang Zhu, Fang Song, Biao Liu, Chuantao Zheng, Mingquan Pi, Yu Zhang, Yiding Wang

Published in

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. Volume 364. Issue Pt 2. Pages 128619. Aug 19, 2026. Epub Aug 19, 2026.

Abstract

Mid-infrared plasmonic metasurfaces are promising for label-free biomolecular fingerprinting. This study presents an asymmetric hook-shaped nanoantenna array for surface-enhanced infrared absorption (SEIRA) spectroscopy. Through systematic 3D finite-difference time-domain (FDTD) simulations, the influence of antenna thickness, shape, lattice periodicity and polarization angle on optical response and near-field enhancement were investigated. The optimized geometry exhibits an absorption peak at ∼9.67 μm, coinciding with the characteristic vibrational modes of glucose. When configured as a glucose sensor incorporating background correction and multi-peak fitting algorithms, the platform delivers a 22.24-fold boost in extinction intensity and an enhancement factor (EF) exceeding 10⁴ relative to a conventional CaF₂ substrate. Preliminary tests in fetal bovine serum (FBS) indicate the robustness of the extracted glucose vibrational features in a complex matrix. All data points fall within Zone A of the Clarke Error Grid (CEG), and Bland-Altman (BA) analysis shows good agreement, with a root mean square error (RMSE) of 4.88 mg/dL. No discernible interference from the FBS background was observed.

PMID:
42633737
Bibliographic data and abstract were imported from PubMed on 24 Aug 2026.

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