[Non-invasive prenatal testing: The simulation application of QIAxcel Advanced automated nucleic acid analysis system in fetal Diego blood group detection].

Authors

Yongqiang Li, Yufeng Wang, Jiahui Huang, Qiurong Liu, Yuanming Wu

Published in

Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. Volume 42. Issue 8. Pages 708-714.

Abstract

Objective To establish an QIAxcel Advanced automatic nucleic acid analysis system with high sensitivity and specificity for detecting the fetal Diego blood group. Methods Preliminary simulation of non-invasive prenatal detection of different proportions of fetal free DNA content in maternal plasma. QIAxcel Advanced automatic nucleic acid analysis system was used to detect the Di^a antigen sequences in simulated DNA to verify the accuracy and sensitivity of the method. ResultsQIAxcel Advanced automatic nucleic acid analysis system successfully detected the Di^a antigen sequences in different proportions of simulated DNA. Moreover, the sex-determining region Y (SRY) gene sequences of male fetuses in different proportions of simulated DNA were detected. Conclusion The QIAxcel Advanced automatic nucleic acid analysis system can be used for non-invasive prenatal detection of the DI*A genotype in Diego blood group system.

PMID:
42634905
Bibliographic data and abstract were imported from PubMed on 24 Aug 2026.

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