Evaluating deucrictibant for the treatment of hereditary angioedema.

Authors

Van Bui, Shane Stone, Bharosha Bhattarai, Long Hoang Luong, Mai Thi Vu, E Pelinsu Aydin, Timothy Craig

Published in

Expert opinion on pharmacotherapy. Aug 24, 2026. Epub Aug 24, 2026.

Abstract

Hereditary Angioedema (HAE) is a rare disease affecting approximately 1 in 50,000 people. It results in angioedema of the skin, abdominal tract and upper airway that results in disfiguration, abdominal pain and potential for asphyxia. Early therapies for HAE have significant drug burden due to intravenous administration (C1-inhibitor) or adverse events (androgens); however, newer therapies have reduced injection requirements, and some are oral. Over the past 6 years two oral therapies have been developed for HAE to include berotralstat for long term prophylaxis (LTP) and sebetralstat for on-demand therapy (ODT). Presently, deucrictibant, another oral HAE therapy, is under investigation and appears effective for LTP and ODT.
This manuscript summarizes the development, pharmacokinetics, pharmacodynamics, and currently available clinical evidence regarding deucrictibant in HAE management.
Deucrictibant is a promising therapeutic agent with a well-defined mechanism of action. Published and ongoing clinical studies demonstrate favorable safety, tolerability, and efficacy profiles for both LTP and ODT, offering a convenient oral alternative that may reduce treatment burden and improve patient quality of life.

PMID:
42635583
Bibliographic data and abstract were imported from PubMed on 24 Aug 2026.

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